National Breast Cancer Coalition

DNA.Land

DNA.Land: The Breast Cancer Database

The National Breast Cancer Coalition has partnered with the New York Genome Center to develop a large scale resource to study breast cancer. This project asks women and men who have participated in genealogy tests to answer questions about breast cancer, including their family history. These genomic data, along with answers from the breast cancer questionnaire, developed by NBCC trained advocates and researchers, will be used to develop a large-scale database that researchers can use to identify genetic variants that impact risk and recurrence of the disease. 

The new database will serve as an important tool for breast cancer researchers and has the potential to help develop approaches to prevention, new treatments and therapies for the disease. NBCC and DNA.Land scientists need participation from as many participants as possible who have, or have had breast cancer or have a first degree relative with a history of breast cancer.

This project expands the web platform DNA.Land to include a focus on breast cancer. DNA.Land is a web platform to securely collect genotype and phenotype information from individuals who have obtained genomic wide information using Direct to Consumer (DTC) genomics companies. DNA.Land is designed with robust privacy protections, proper consent and systematic collection of phenotypes. A segment of the DNA.Land website has a clinical questionnaire specific to breast cancer to collect clinical and outcome data. 

If you have had your DNA sequenced through a DTC genomic company such as 23andMe, Ancestry DNA, or FamilyTreeDNA, you can be part of this project. Please visit DNA.Land for more information. 

If you have not yet had your DNA sequenced, there are easy to follow instructions on how to obtain genomics information from the three most popular DTC websites on DNA.Land.

For more information or to ask questions, please email nbccdnaland@breastcancerdeadline2020.org.

Frequently Asked Questions:

How do I participate?

If you have had your DNA sequenced through one of the DTC genomic companies, you can visit DNA.Land and upload your information directly to the website. After uploading our information, you select the option to complete the breast cancer clinical questionnaire. 

If you have not had your DNA sequenced, you can visit any of the three DTC genomic companies, 23andMe, Ancestry DNA, My Heritage, or FamilyTreeDNA, and have your DNA sequenced. There is a fee to have your DNA sequenced which is different at each site. Once you have your DNA sequenced, you can visit DNA.Land and upload your information and complete the clinical questionnaire. 

I do not have a history of breast cancer, should I still participate?

Yes, even if you do not have a history of breast cancer, your participation is important to this study. To find genetic features that are linked to cancer, researchers must compare genomes of people with cancer to those without.

Who will have access to my DNA information and questionnaire responses?

Your data will only be used by NBCC approved researchers for future studies. These researchers will be required to adhere to a code of conduct that prohibits re-identification of the data or data misuse.