National Breast Cancer Coalition

NBCC's Clinical Trials Partnerships

Upcoming Clinical Trials for Women with Metastatic Breast Cancer

NBCC is currently partnering with BioMarin and Pfizer on three upcoming clinical trials for women with metastatic breast cancer. Intervention offers the potential of improving the length and quality of life for patients already diagnosed with metastatic breast cancer. Trial accrual has begun for all three studies.

NBCC advocates have been involved in many ways on these trials in the development of the protocols, as members of the Date Safety Monitoring Board, as reviewers of educational materials and consent forms and in conducting outreach activities to educate the public about the trials.

EMBRACA clinical trial for the PARP inhibitor BMN 673 (BioMarin)

  • Purpose of the study:   To evaluate the efficacy and safety of BMN 673 in the metastatic setting.
  • Eligibility:  Women with the BRCA1 or BRCA 2 mutation and locally advanced or metastatic breast cancer.  Other eligibility criteria and trial details can be found at  http://clinicaltrials.gov/ct2/show/NCT01945775.

PALOMA 2 clinical trial for the CDK 4/6 inhibitor Palbociclib (Pfizer).

  • Purpose of study:  To evaluate the efficacy and safety of Palbociclib with letrozole in the metastatic setting.
  • Eligibility: First-line treatment of postmenopausal women with ER+/HER2- locally advanced or metastatic breast cancer.  Other eligibility criteria and trial details can be found at http://clinicaltrials.gov/show/NCT01740427

PALOMA 3 clinical trial for CDK 4/6 inhibitor Palbociclib (Pfizer).

  • Purpose of study: To evaluate the efficacy and safety of Palbociclib with fulvestrant in the metastatic setting.
  • Eligibility: Women with HR+/HER2- locally advanced or metastatic breast cancer who progressed on or after prior endocrine therapy. Other eligibility criteria and trial details can be found at  http://clinicaltrials.gov/show/NCT01942135 .

NBCC is recruiting advocates to help educate the public and potential participants about these trials. If you are interested in helping NBCC’s outreach effort for any of these trials, please contact us at clinicaltrials@breastcancerdeadline2020.org